Seznam abstraktů 2022: PLENÁRNÍ SEKCE

There is a high demand to develop innovative and cost effective devices with interest for health care beside environment diagnostics, safety and security applications. The development of such devices is strongly related to new materials and technologies being nanomaterials and nanotechnology of special role. We study how new nanomaterials such as nanoparticles or graphene can be integrated into simple sensing platforms thanks to their advantageous properties. Beside plastic platforms physical, chemical and mechanical properties of cellulose in both micro and nanofiber-based networks combined with their abundance in nature or easy to prepare and control procedures are making these materials of great interest while looking for cost-efficient and green alternatives for device production technologies. These devices should be REASSURED: Real-time connectivity, Ease of specimen collection, Affordable, Sensitive, Specific, User-friendly, Rapid, Robust, Equipment-free, Delivered to those who need it. How to design simple plastic/paper-based biosensor architectures including wearables through printing or stamping? How to tune their analytical performance upon demand? How one can couple nanomaterials with paper/plastics and what is the benefit? Which are the perspectives to link these simple platforms and detection technologies with mobile communication? I will try to give responses to these questions through various interesting applications related to protein, DNA and even bacteria and viruses with extreme interest for clinical emergency applications. The developed platforms and related technologies are related to ubiquitous methods that would be quite important for democratising diagnostics and improving healthcare coverage all over the world.

Nanomedicine is the medical application of nanotechnology. Nanomedicine ranges from the medical applications of nanomaterials and biological devices, to nanoelectronic biosensors and biomarkers. Current nanomedicine issues involve understanding and controlling the interactions (and toxicity) of nanomaterials with biological fluids, cells and tissues. In this lecture, I will underline the importance of soft condensed matter approaches to face the challenges of nanomedicine, and demonstrate the benefits of such strategies. I will provide instances of particles used as diagnostic and therapeutic agents for the treatment of major diseases, including cancer [1,2]. The emphasis will be on the nanomaterial-biological fluid interface, which is now recognized as a key factor in determining the fate of nanoparticles in vivo [3]. Finally, I will show how, under certain conditions, particles can be translated into microdevices [4] and manipulated to allow the measurement of biomarkers of cancer cell metastatic properties [5]. REFERENCES: [1] J.-F. Berret, A. Graillot, Langmuir, 38 (2022) 5323-5338.; [2] M.S. Lord, J.F. Berret, S. Singh, A. Vinu, A.S. Karakoti, Small, 17 (2021) 2102342.; [3] M. Falahati, F. Attar, M. Sharifi, T. Haertlé, J.-F. Berret, R.H. Khan, A.A. Saboury, Biochim. Biophys. Acta, Gen. Subj., 1863 (2019) 971-991.; [4] L.-P.-A. Thai, F. Mousseau, E. Oikonomou, M. Radiom, J.-F. Berret, ACS Nano, 14 (2020) 466-475.; [5] J.-F. Berret, Nat. Commun., 7 (2016) 10134.